We included 75 studies (36 from the original review and 39 from our updated review) enrolling a total of 7200 participants.Īmong primary outcomes, 36% of participants receiving IV paracetamol/propacetamol experienced at least 50% pain relief over four hours compared with 16% of those receiving placebo (number needed to treat to benefit (NNT) = 5 95% confidence interval (CI) 3.7 to 5.6, high quality evidence). However, we found very few studies that included children, so this is an area that requires further investigation. However, patients receiving IV propacetamol complained of pain at the site their medication was infused at more often than those receiving placebo or IV paracetamol.ĭue to the amount of data already included in our review, we think it is unlikely that any new studies will change our conclusions. Low quality evidence showed that IV paracetamol and IV propacetamol produced few side effects. Direct comparisons with other painkillers, such as morphine and anti-inflammatories, did not show large differences (if any) in effectiveness, although this may have been due to the small numbers of patients studied. We found high quality evidence that IV paracetamol or IV propacetamol provided pain relief for four hours for about 36% of people versus 16% of those receiving placebo. Our updated review included data from 75 studies of 7200 patients with moderate-to-severe pain after an operation.
In February 2016, we searched for clinical trials looking at intravenous (IV) formulations (solutions that can be administered directly into a vein) of paracetamol (either IV paracetamol or IV propacetamol) and how they might manage pain after surgery. Pain is commonly experienced after surgical procedures and multiple medications (e.g., painkillers) are routinely used to control it.
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